#190 at the time of writing.
John Nash's battle with schizophrenia - the Hollywood version rather than being comprehensively accurate, but the spirit of the tale rings true.
The way his delusions were handled in this film was particularly effective for me. I understood the helplessness he must have felt, the seductiveness of the mental trap he found himself in. And also the fear and frustration that his wife had to overcome to support him (Jennifer Connelly in an Oscar-winning performance; the movie also won Best Picture and Best Adapted Screenplay).
According to IMDb's trivia, this was named as one of "The 20 Most Overrated Movies Of All Time" by Premiere magazine. Which makes me think that Premiere don't know squat. (Looking at the rest of the list only confirms it.)